Abstract: On the basis of the geological backgrounds and characteristics of the Zhongdong fluorite deposit in Wuhua County, Guangdong Province, this study conducted comprehensive discussion on the wall-rock alteration, ore types, vertical zoning of mineralization, and spatial distribution of useful components so as to better understand theore-forming mechanism and ore-controlling factors of this deposit. Detailed analysis of various prospect engineering and test data suggest that the mineralization is characterized by multi-stage and vertical zoning with the useful component(CaF₂)changing along horizontal direction and vertical direction. It can beinferred that the deposit belongs to high temperature hydrothermal fluorite-quartz type deposit and the stratigraphic lithology, structure, magmatic rocks arethe main ore-controlling factors of the fluorite deposit. This study has practical guiding significances for exploration and study of deposits of the same type.