Abstract: This paper analyzed the data of soil geochemistry survey at the scale of 1:10000 in the Dongxi-Nanguanling gold ore deposit using the methods of mathematical geology. The results show that the Au anomalies and other related anomalies are mainly controlled by NW-trending tectonic fracture zone. R-cluster analysisof the soil geochemical data shows that twelve trace elements can be grouped into four categories.(1)F1 factor(including Cu, Pb, Zn and Au)is the combination of medium-temperature ore-forming elements and represents the sulfide mineralization factor.(2)F2 factor(including Sb, As, W and Mo)may reflect characterof multiple superimposed halos.(3)F3 factor including Bi, Hg and Sn is the same as F2 factor.(4)F4 including Au and Ag reflects the combination of ore-forming elements. The F4 factor score for 1910 samples from the study area was calculated. The contour map with the F4 factor score>0 is similar to that of the Auanomalies, and this is highly coupled with the orebodies identified. Authors suggest that the anomalous areas and Au anomalous areas defined by F4 factor scoresare of good ore-finding prospecting and should be the key exploration regions.