Abstract: The uranium deposit in the Lianshanguan area, which occurs in the Precambrian strata, is one of the few unconformity-type uranium deposits in China. This study carried out geochemical analysis of the Lianshanguan migmatitic granite. The geochemical characteristics of the main elements and trace elements indicate their petrogenesis and tectonic setting. The migmatitic granites belong to high Si and alkali, low Ti calc-alkalic series rocks, characterized by high REE content(enrichment of LREE), moderately negative Eu anomaly, relatively enrichment of U, La and P and depletion of Ba, Ta, Nb, Sr and Ti. The study shows that the migmatitic granites are characteristic of S-type granite. The protolith is the felsic rocks derived from the middle and upper crust and the migmatitic granite may be formed at the tectonic setting of rifting and extension of the Archean craton.