Abstract: Magmatic hydrothermal gold polymetallic deposits related to the Yanshanian granite is one of the important deposit types in southern Anhui. On the basis of study of typical ore deposits in this area, this paper establishes a prospecting geological prediction model for gold polymetallic deposits through analyzing geological body, metallogenic tectonics and metallogenic structural surface, mineralization features in the Xiuning-Shexian region of Anhui Province. This model fully expresses geologic features of known and conjectural deposits(ore bodies)in the integrated exploration area, and this is of some theoretical guidance and practical value for gold polymetallic ore exploration in southern Anhui.