Abstract: The Luzong volcanic rock ore cluster area is an important Fe-Cu-S polymetallic metallogenic belt in the Middle and Lower Reaches of the Yangtze River. Based on prospecting achievements in the southeastern area in recent years, four metallogenic series have been identified for this area: skarn-type Fe-Cu-Au-S mineralization series associated with high-K calc-alkaline series intrusions, volcanic-subvolcanic hydrothermal vein-type copper polymetallic and iron series related to with shoshonite, sedimentary-superimposed iron-copper metallogenesis series associated with magmatism, and Fe-Cu-Pb-Zn uranium mineralization series related to alkali-rich intrusive rocks. This paper describes the geological characteristics and metallogenic regularity of four representative deposits of four metallogenic series. Metallogenic time has been classified into “Two Period and Three Stages” and mineralization distribution is mainly controlled by Carboniferous to Jurassic basement strata of the basin, base faulting, volcanic structure, southeastern A-type granite belt and high-K calc-alkaline series intrusive belt. Based on the above analyses, the metallogenic model in the study area is established.