Abstract: Jinkeng Cu-Sn-Pb-Zn polymetallic deposit in Jiexi County, Guangdong Province is tectonically located in the Lianhuashan deep fault zone in the Huiyang-Meixian Neocathaysian tectonic belt. In order to explore the genesis of ore deposit and ore controlling factors, this study carried out field geological survey and comprehensive analysis of geological data. The results show that the deposit belongs to metamorphic hydrothermal type of Cu-Sn-Pb-Zn deposit driven by tectonic activity, characterized by extensive mineralization, large scale, well developed ore-bearing veins, varied grades, multiple stages. Lithology, structure and magmatic rocks are the main ore controlling factors. NE-to NNE-trending Neocathaysian fractured zone and schistositilized zone and its accompanying faults are the major ore-bearing structures. Dynamic metamorphic belt is an important ore controlling factor for the Jinkeng Cu-Sn-Pb-Zn deposit. Therefore, the Lianhuashan deep fault is of exploration potential for the Jinkeng-type deposits.