Abstract: Liangkeng Mo-W ore district is located in the southeast of the fault belt in northeastern Jiangxi and within the poly-metallic metallogenic belt of the northern Qin-Hang mineralization belt. It has an excellent metallogenic condition. Based on the geological characteristics of the Liangkeng Mo-W deposit including geomorphology, geology and mineralization, this paper defines six integrated anomalous areas using the soil geochemical anomalies. The three advantageous anomalous areas were selected to carry out engineering testing, and several Mo-bearing ore bodies and W-bearing ore bodies have been found. Promising exploration results have been obtained, and this will expand a new field for prospecting in the southeastern part of the fault belt. Therefore, this study shows that soil geochemical measurement has significant application effects in the prospecting of the Liangkeng Mo-W ore district and will provide some references for future prospecting on the both sides of the fault belt in northeastern Jiangxi Province.