Abstract: Based on the geologic characteristics of three reticulate layers’ profiles in southern Anhui Province, the study analyzed their formation time and possible origins. The results show that the earliest and latest formation times of reticulate layers is 838±83 ka and 29～31 ka, respectively. Multiple layered ferromanganese nodules have been found to occur in the study layers in southern Anhui Province. The formation of their matrixes is characterized by variety with the Fancun profile belonging to fluvial facies accumulation and the profiles in Caicun and Yulin towns to lacustrine facies accumulations.