Abstract: The Wugudun Ag-Mo polymetallic deposit, located in the Guichi ore cluster area of the middle-lower Yangtze metallogenic belt, belongs to porphyry-skarn-hydrothermal deposit. By studying the characteristics of ore deposits, metallogenic geological conditions, analyzing prospecting potential, and using metallogenic vacancy theory, we predict prospecting directions for orebodies of different types. It is believed that this area has the prospect of discovering medium-large polymetallic deposits, which is of great significance for finding blind orebodies in mining areas and surrounding areas.