Abstract: Taking the Dawangfu-Jiangshan Pb-Zn-Au deposit in Fengyang, Anhui Province as an example,the optimal sampling density of short-hole drilling geochemical survey in shallow covered region is further discussed through the systematic 1:50 000 short-hole drilling geochemical survey. The average density of actual sampling is 16 holes/km², which is evenly diluted into 8 holes/km², 4 holes/km² and 2 holes/km², and the single element geochemical anomaly maps are drawn respectively. Through comparative study, it is found that the suitable sampling density is 4 holes/km² in the stage of 1:50 000 short-hole drilling geochemical survey, which can reflect the characteristics of medium-sized deposits similar to Dawangfu-Jiangshan Pb-Zn-Au deposit.