Abstract: The Huangmeijian area of Anhui Province, located in the southeastern margin of Lujiang-Zongyang volcanic basin, has superior geological conditions for uranium mineralization. The metallogenic type is epithermal uranium deposit related to alkaline rocks, and the uranium mineralization is controlled by strata, faults, magmatic rocks and postmagmatic hydrothermal activities. To study the relation between uranium mineralization and geophysical characteristics in this area, the geophysical characteristics of typical uranium deposits/occurrences are studied by comprehensive geophysical prospecting methods such as ground γ-ray spectrometric survey, gamma total measurement and induced polarization (IP). The results show that the uranium deposits/occurrences are generally located in the gamma high field and energy spectrum uranium anomaly field to high field gradient zone, with the electrical characteristics of low resistance and high polarization for ore-bearing structure faults. By summarizing the geological-geophysical characteristics of uranium deposits (occurrences) of this type, two metallogenic prospect areas are delineated, which provides basis for further work and reference for prospecting the same type of uranium deposits.