Abstract: The Liushuzhuang area of Mingguang City is located in the junction of North China tectonic plate and Yangtze tectonic plate, which is in the east side of the middle section of the Tanlu (Tancheng-Lujiang) fault zone. There are many gold-copper-polymetallic mineral occurrences within and around the area, with favorable metallogenic background and geological conditions. Deep soil geochemistry, IP ladder, magnetic method and Controlled Source Audio Magnetotelluric (CSAMT) method were carried out to search for gold-copper-polymetallic ore in the area. According to high and low resistance contact geophysical anomaly and zonal geochemical anomaly, three NW faults (numbered F1, F2, F3) were speculated and three prospecting targets (numbered target I, II, III) were delineated. Target I is characterized with high resistance, high polarization and positive magnetic anomaly, according to the verification of one borehole(ZK301) plugged in the target I area, the geophysical anomaly was turned to be caused by pyritization and chalcopyritization, and no gold mineralized body was found. The anomaly features of gold elements are obvious and distribute in strip-shaped along the main ore-controlling structural lines in the target I and II, indicating a potential prospecting direction with the occurrences of gold (copper). Based on the results of geological and geophysical-geochemical exploration, it is suggested that the next step of prospecting in the study area should focus on the search of possible metallogenic structures.