Abstract: Based on the analysis of hydro-geochemical data obtained recently, this study assessed exposure risk of high Fe and Mn groundwater from Huaihe River Plain in eastern China using Indicator Kriging method, as well as discussed its origin. The results showed that Fe and Mn were the main chemical substances affecting groundwater quality, indicating obvious spatial variability. The peak value of Fe and Mn risk probability were distributed similarly in spatial pattern. The high-risk areas of Fe and Mn presented an island distribution, and the hazard risk of deep groundwater were significantly reduced against the shallow counterpart. The high risk zone of Fe in shallow groundwater covers 1 257.15 km², accounting for 0.07％ of the study area, and the counterpart in deep groundwater was 476.93 km², accounting for 0.03％, respectively. The high risk zone of Mn in shallow groundwater covers 35 883.16 km², accounting for 19.19％, while its counterpart in deep groundwater was 1 269.30 km², accounting for 0.07％, respectively. The high Fe and Mn groundwater was of in-situ origin, and Fe and Mn were derived from geogenic iron and manganese minerals in aquifers by reductive dissolution. This paper carried out research on exposure risk of high Fe and Mn groundwater from Huaihe River Plain, which may provide guidance for the regionalization of drinking groundwater safety.