Abstract: Ganzhou Basin, located on the north side of the eastern part of the EW-trending complex tectonic belt in Nanling Range, China, is controlled by the NE-trending structure. With well-developed late Cretaceous red beds in the region, it has been a representative red basin in the eastern part of South China. The basin is basically a closed south-east-inclined dustpan-like lake basin, with Li enriched in magmatic rocks of the Late Caledonian, stage II and III of Early Yanshanian and Late Yanshanian, and high Li content in sandy rocks of the Late Cretaceous Zhoutian Formation in the periphery of the basin. The exploration results indicate clues of brine-type lithium ores found in the basin, revealing a lithium-bearing brine layer with aquifer thickness of 17~37 m and LiCl content of 188~457 mg/L in Tankou surrounding area. The major lithium-bearing layer is in the middle of the Late Cretaceous Zhoutian Formation located in the sedimentary center of the basin, dominated by purple red and brownish purple fine sandstone, gray-brown fine sandstone interspersed with siltstone, and purple red siltstone. The main prospecting signs of lithium brine include remote sensing image of light red tone and purple red tone, stratiform closed low resistance anomaly, water geochemical anomaly of high chlorine, low potassium and low bromine, the sedimentary center of depression basin under less fracture influence and fine clastic rock in the middle of Zhoutian Formation. Compared with Jitai Basin and Huichang Basin, brine-type lithium resources in this basin are found to have a great potential and good prospecting prospect. It is expected to achieve a new breakthrough by strengthening comprehensive prospecting.