Abstract: To study the comprehensive evaluation index system for regional mining environment, this paper took the upper-middle reaches of Le’an River as a case study and selected 15 indicators from natural geography, basic geology, mine exploitation and geological environment, and used the grid of 1.0×1.0 km as the evaluation unit. The evaluation employed analytical hierarchy process-comprehensive index method, the results of which show that there are 18 units in the most severely affected area (grade 4) in the study area, mainly distributed in the mining areas of copper and gold deposits. There are 107 units in the severely affected area (grade 3), mainly distributed in the mining areas of coal mines and the non-mining areas outside the copper and gold deposits. The field survey verified that the comprehensive evaluation results were highly consistent with the actual situation, proving a certain practical value of the evaluation index system, which can provide reference for regional mine environmental assessment on metals deposits and coal mines.