Abstract: The Xijiazhuang gold-lead-zinc polymetallic deposit is a newly discovered polymetallic deposit in the western section of the Bengbu uplift. The prospecting on it has achieved a breakthrough in the deep covered areas of the northwest Anhui. The study of the metallogenic stages and chronology of ore-forming rock mass of the Xijiazhuang deposit is of great significance for understanding the genesis, prospecting direction, and regional metallogenic regularity of this deposit. Through detailed field geological observation and microscopic identification, this paper divided the mineralization of gold-lead-zinc polymetallic deposits into three mineralization periods (skarn period, hydrothermal period, and supergene period) and six mineralization sub-stages (early anhydrous simple skarn stage, late water-bearing complex skarn stage, quartz sulfide stage, early carbonate stage, late carbonate stage, and supergene stage) according to their genesis epoch, intergeneration and the relation between host-rock alteration and mineralization, among which the quartz sulfide stage and early carbonate stage are the main. Utilizing the zircon LA-ICP-MS U-Pb dating, the ages of the major ore-forming rocks such as granodiorite porphyry and quartz monzonite porphyry in the mining area are determined to be (114.77±0.48) Ma and (113.70±0.51) Ma respectively, which indicate that it is the product of the early Cretaceous magmatism .